Western Illinois University: Macomb Campus
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Dr. Jin Jin , Ph.D.
MWF 9:00 - 10:30 or by Appointments
B. S. Jilin University; M. S. Nankai University; Ph.D. from State University of New York at Albany, 2006; Post-Doctoral Fellow: Rensselaer Polytechnic University (2006-2007)
Organic Chemistry, Advanced Organic Chemistry
Antioxidants are substances that may protect cells from the damage caused by unstable molecules known as free radicals. Antioxidants can block the chain reaction caused by free radicals before cell damage can result. Selenium antioxidants are one of the important types of antioxidants. All antioxidants have a chemical element referred to as a “redox” potential, which is the measurement of their ability to be oxidized. Experiment evidence has shown that incorporation of silicon atom or Si-Si bond at the beta position of Se atom in organo selenium compounds will enhance the activities of these compounds by lowering the redox potential. This is due to the beta-silicon effect or beta-disilanyl effect.
The objective of my research is to design and synthesize new organic selenium antioxidants with more potent antioxidant activities compared to the currently available selenium antioxidants. Based on the currently known selenium antioxidants such as seleno cystein, seleno cystamine, 3,3-diselenobispropionic acid, etc., the structures and synthesis of some new organo selenium antioxidants with incorporation of silicon atom or silicon-silicon bond at the beta position are proposed. Their antioxidant abilities will be evaluated by testing their redox potentials and different antioxidant capacity assays.
Current Research Funding
WIU University Research Council Grant, 2011-2012
Shaozhong Zhang, Kranthi Karra, Adam Koe, Jin Jin, Catalyst free one-pot synthesis of symmetrical diaryl tellurides with Te0/KOH; Tetrahedron Letters, 2013, 54, 2452-2454.
Shaozhong Zhang, Kranthi Karra, Christina Heintz, Erica Kleckler, Jin Jin, Microwave-assisted Cu2O-catalyzed one-pot synthesis of symmetrical diaryl selenides from elemental selenium, Tetrahedron Letters, 2013, 54, 4753-4755.
Electrochemical and chemical Oxidation of Dithia-, diselena-, ditellura-, selenathia- and tellurathia- mesocycles and stability of the oxidized species. Evans D; Gruhn N; Jin J; Li B; Lorance E; Okumura N; Macia-Ruvalcaba N; Zakai U; Zhang S-Z; Block E; Glass R, Journal of Organic Chemistry 2010; 75: 1997-2009.
Syntheses of novel high affinity ligands for opioid receptors. Wentland MP, Lou R, Lu Q, Bu Y, Denhardt C, Jin J, Ganorka R, VanAlstine MA Guo C, Cohen DJ, Bidlack JM. Bioorganic & Medicinal Chemistry Letters 2009; 19: 2289-2294.
Chemistry of Mixed Sulfur-, Selenium-, or Tellurium- and Silicon-, or Tin-Containing Heterocycles. Block E, Glass RS, Gruhn NE, Jin J, Lorance E, Zakai UI, Zhang S-Z. Phosphorus, Sulfur and Silicon and the Related Elements 2008; 183: 856-862.
Interaction of C-Si, C-Sn, and Si-Si s -Bonds with Chalcogen Lone Pairs Glass RS, Block E, Gruhn NE, Jin J, Lorance E, Zakai UI, Zhang S-Z. Journal of Organic Chemistry 2007; 72: 8290-8297.
Synthesis, Structure and Chemistry of New, Mixed Group 14 and 16 Heterocycles: Nucleophile-Induced Ring Contraction of Mesocyclic Dications. Block E, Dikarev EV, Glass RS, Jin J, Li B, Li X, Zhang S-Z. Journal of the American Chemical Society 2006; 128: 14949-14961.